Camelbak MULE
With this pack I use my leg holster for my .40 Sig Sauer Pro. It is much more comfortable while hiking and allows for a rapid draw if I come across a charging animal or person.
As always this is what works for me. It is up to you to decide what works well for you. The best advice I can provide is trial and error. Get out and try all your equipment so you know what works and what doesn't.